Tofacinix CAS:477600-75-2

Tofacitinib is an orally available inhibitor of Janus kinases(JAK),with immunomodulatory and anti-inflammatory activities.Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription(STAT)signaling pathway.This may decrease the production of pro-inflammatory cytokines,such as interleukin (IL)-6,-7,-15,-21,interferon-alpha and -beta, and may prevent both an inflammator response and the inflammation-induced damage caused by certain immunological diseases.JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis,immunity and inflammation.

msds---Tofacinix